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For over 25 years Cochrane has produced high-quality systematic reviews and played a key role in the world of evidence-based medicine. It has fiercely guarded its independence and sought to promote a wider and better understanding of the healthcare research. What challenges and opportunities lie ahead, in an era full of ?€?fake news?€?? And one in which there is an increasing belief that the world?€?s great problems ?€¡° in health care and beyond - will never be solved by academia alone.